DiffAb
Diffusion model for antigen-specific CDR design and optimisation.
Developer: Shitong Luo et al. (academic release)
Overview
- Developer
- Shitong Luo et al. (academic release)
- Category
- Antibody-specific design
- Commercial rights
- Commercial OK
- Commercial cost
- Free commercially
- Compute
- Single GPU
- Open weights
- Yes
- Last verified
Capabilities
Designs or redesigns CDRs against a given antigen. Input: an antibody-antigen complex structure (or a docked framework) and the CDR to vary; output: sampled CDR sequence-structure pairs, supporting de novo design, sequence-structure co-design and optimisation of an existing antibody.
When to use it
A well-known, easy-to-run baseline for CDR redesign when you already have a complex structure - good for optimisation and for sanity-checking newer tools. It needs a starting complex; it will not find an epitope for you.
Input / Output
- Input
- an antibody-antigen complex structure (or a docked framework) and the CDR to vary
- Output
- sampled CDR sequence-structure pairs, supporting de novo design, sequence-structure co-design and optimisation of an existing antibody
Compute
Single GPU. Other tools with this compute profile →
Commercial Licensing
Commercial rights — may a company use it?
Commercial use OKLicence as writtenApache License 2.0
Apache-2.0 LICENSE in the repo; the trained checkpoints are distributed from the same repository with no separate terms. It does depend on antibody structure tooling, which you should licence-check separately.
The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.
Commercial cost — is commercial use free of charge?
Free for commercial useFree: Apache-2.0 code and checkpoints, no fee.
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- github.com/luost26/diffab
- Licence sources
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