ANARCI

Numbers antibody and TCR sequences (IMGT, Kabat, Chothia).

Developer: OPIG, University of Oxford

Commercial use OKFree for commercial use

Overview

Developer
OPIG, University of Oxford
Commercial rights
Commercial OK
Commercial cost
Free commercially
Compute
CPU
Open weights
Yes
Last verified

Capabilities

Antibody numbering. Input: antibody or TCR sequences (FASTA); output: the same sequences numbered in IMGT/Kabat/Chothia/Martin with germline V/J assignment and CDR boundaries - the preprocessing step almost every antibody tool expects.

When to use it

The basic plumbing for any antibody pipeline: numbering, CDR definition, species assignment. Depends on HMMER germline HMMs and can fail on heavily engineered or truncated sequences.

Input / Output

Input
antibody or TCR sequences (FASTA)
Output
the same sequences numbered in IMGT/Kabat/Chothia/Martin with germline V/J assignment and CDR boundaries - the preprocessing step almost every antibody tool expects

Compute

CPU. Other tools with this compute profile →

Commercial Licensing

Commercial rights — may a company use it?

Commercial use OK

Licence as writtenBSD 3-Clause style license (LICENCE file, 2019 Deane et al.)

The LICENCE file contains BSD 3-Clause redistribution terms with no field-of-use restriction; GitHub's license detection also reports BSD-3-Clause.

The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.

Commercial cost — is commercial use free of charge?

Free for commercial use

Nothing to pay: the licence read at the source grants commercial use with no fee, and the code and weights are public downloads. You still pay for your own compute.

Original sources — read on 15 Oct 2026
  1. raw.githubusercontent.com/oxpig/ANARCI/master/LICENCE

Price and rights are separate: this panel is about money, the panel above is about permission.

  • Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
  • Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
  • Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
  • Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.

Model Weights

Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.

Dependencies

Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.

Official References

Official site / repo
github.com/oxpig/ANARCI

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