PepMLM
Masked-language-model generation of linear peptide binders from target sequence alone.
Developer: Chatterjee Lab (Duke / Programmable Biology)
Overview
- Developer
- Chatterjee Lab (Duke / Programmable Biology)
- Commercial rights
- Non-commercial
- Commercial cost
- No commercial option
- Compute
- Single GPU
- Open weights
- Yes
- Last verified
Capabilities
Generates peptide binders without any structure. Input: the target protein sequence and the desired binder length; output: candidate peptide sequences, produced by masked-token generation conditioned on the target - cheap enough to run on a laptop-class GPU.
When to use it
Fast sequence-only peptide binder ideas when you have no structure at all. The access conditions - no patents on generated sequences, authorship on resulting papers - are disqualifying for most company work; read them before downloading.
Input / Output
- Input
- the target protein sequence and the desired binder length
- Output
- candidate peptide sequences, produced by masked-token generation conditioned on the target - cheap enough to run on a laptop-class GPU
Compute
Single GPU. Other tools with this compute profile →
Commercial Licensing
Commercial rights — may a company use it?
Not for commercial useLicence as writtenModel card declares MIT, but access is gated behind terms that require non-commercial use
A genuine contradiction, read on the date shown: the Hugging Face card for ChatterjeeLab/PepMLM-650M declares license: mit, while the same card's gated-access fields make you tick 'I agree to use this model for non-commercial use ONLY', plus authorship, data-sharing and no-patent conditions. The GitHub repo publishes no LICENSE file at all. Those access terms are what you actually accept to obtain the weights, so treat it as non-commercial until the authors reconcile the two.
The licence limits use to non-commercial purposes; a company needs a separate agreement.
Commercial cost — is commercial use free of charge?
No commercial option at any priceNo money changes hands, but the access agreement demands non-commercial use and rights concessions, so there is no commercial path. No commercial licence is offered.
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- github.com/programmablebio/pepmlm
From the makers of FoldScout
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