EvoBind
In-silico directed evolution of cyclic and linear peptide binders with AlphaFold.
Developer: Patrick Bryant (Stockholm University / SciLifeLab)
Overview
- Developer
- Patrick Bryant (Stockholm University / SciLifeLab)
- Commercial rights
- Unverified
- Commercial cost
- Cost unverified
- Compute
- Heavy GPU
- Open weights
- No
- Last verified
Capabilities
Evolves a peptide binder against a target without needing a known binding site. Input: target sequence/structure and optional target residues; output: optimised peptide (including macrocyclic) sequences with AlphaFold-predicted complexes, by iterative mutation under an AlphaFold-based objective.
When to use it
Interesting for peptide and macrocycle binders where you have no structural starting point. Treat the missing licence as a blocker for commercial use until the author states terms - ask him; it is usually a one-line answer.
Input / Output
- Input
- target sequence/structure and optional target residues
- Output
- optimised peptide (including macrocyclic) sequences with AlphaFold-predicted complexes, by iterative mutation under an AlphaFold-based objective
Compute
Heavy GPU. Other tools with this compute profile →
Commercial Licensing
Commercial rights — may a company use it?
UnverifiedLicence as writtenunverified - no LICENSE file published in the repository
Checked via the GitHub licence API and the repository root on the date shown: the repo publishes no LICENSE file and the README states no terms, so by default no rights are granted and the position is unverified. It also runs AlphaFold2 parameters (CC BY 4.0) underneath, which are themselves fine for commercial use.
We could not find a published statement that settles it (often: the model weights carry no licence). Treat as unknown.
Commercial cost — is commercial use free of charge?
Cost unverifiedNo fee is charged for the code, but with no licence published there is no stated right to use it commercially at any price.
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Weights not openly downloadable. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- github.com/patrickbryant1/EvoBind
- Licence sources
From the makers of FoldScout
From AI Design to Wet-Lab Validation
Designed a promising protein or antibody? Seq2Study helps translate AI-generated sequences into experimental data.
- Protein Expression
- Protein Purification
- Binding Affinity
- Aggregation Assessment
- Stability Evaluation
- Developability Assessment
Get told when a licence changes
Licences on these tools do change. One short email when a status flips or a tool is added. No other use of your address.