ProGen3
Profluent's sparse protein language model family - code open, weights non-commercial.
Developer: Profluent Bio
Overview
- Developer
- Profluent Bio
- Category
- Protein language models
- Commercial rights
- Non-commercial
- Commercial cost
- No commercial option
- Compute
- Heavy GPU
- Open weights
- Yes
- Last verified
Capabilities
Generates and scores protein sequences at scale. Input: a prompt (family/function tags or a partial sequence) for generation, or sequences for scoring; output: generated sequences, or log-likelihood fitness scores used to rank variants. Ships as a CLI for scoring and generation.
When to use it
Academic sequence generation and variant scoring at scale. Commercially, use ESM-2/ESM C or ProtGPT2, all of which are permissive.
Input / Output
- Input
- a prompt (family/function tags or a partial sequence) for generation, or sequences for scoring
- Output
- generated sequences, or log-likelihood fitness scores used to rank variants
Compute
Heavy GPU. Other tools with this compute profile →
Commercial Licensing
Commercial rights — may a company use it?
Not for commercial useLicence as writtenApache License 2.0 (code, LICENSE-CODE); CC BY-NC-SA 4.0 (model weights)
The README states up front that 'the model weights are released under a non-commercial usage license', and its LICENSE section splits them: Apache-2.0 for the code in LICENSE-CODE, CC BY-NC-SA 4.0 for the weights. The Hugging Face model card metadata also declares cc-by-nc-sa-4.0. The code being Apache-2.0 does not help: without the weights there is no model.
The licence limits use to non-commercial purposes; a company needs a separate agreement.
Commercial cost — is commercial use free of charge?
No commercial option at any priceNo fee, but also no commercial grant: CC BY-NC-SA 4.0 excludes commercial use and Profluent publishes no commercial licence price for the weights.
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- github.com/Profluent-AI/progen3
From the makers of FoldScout
From AI Design to Wet-Lab Validation
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Get told when a licence changes
Licences on these tools do change. One short email when a status flips or a tool is added. No other use of your address.