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TEMPRO

Nanobody melting temperature prediction using protein sequence-derived embeddings.

Developer: Jerome A. E. Alvarez and S. N. Dean

Unverified
COMMERCIAL RIGHTSUnverified
COMMERCIAL FEEUnverified
COMPUTEunverified
MODEL WEIGHTSAvailable

Overview

Developer
Jerome A. E. Alvarez and S. N. Dean
Category
developability and stability
Commercial rights
Unverified
License fee
Unverified
Open weights
Yes
Last verified
2026-10-18
Added
2026-10-18

Capabilities

Takes nanobody FASTA sequences, computes embeddings, and estimates melting temperature with pretrained prediction models. Original study discusses a small nanobody melting-point dataset; predictions require DSC/DSF or nanoDSF calibration.

When to use it

Triage VHH thermostability hypotheses; calibrate predicted Tm against measured nanoDSF/DSC in the formulation of interest.

Compute

Compute category: unverified. See original installation instructions or platform terms for specific hardware costs and runtime.

Example use cases

  • Triage VHH thermostability hypotheses; calibrate predicted Tm against measured nanoDSF/DSC in the formulation of interest.

Source-based workflow description. No experimental performance ranking is implied.

Known limitations

  • The repository documents downloadable trained models but a clear license was not established; commercial rights, dataset rights and platform-service fees remain unverified.

Check the original linked sources and the terms of every model dependency.

Commercial licensing

Commercial permission — Unverified

No separately validated code or pretrained-weight license in the available primary repository.

The repository documents downloadable trained models but a clear license was not established; commercial rights, dataset rights and platform-service fees remain unverified.

Original evidence · reviewed 2026-10-18
  1. https://github.com/Jerome-Alvarez/TEMPRO ↗
  2. https://github.com/Jerome-Alvarez/TEMPRO/blob/main/README.md ↗
  3. https://doi.org/10.1038/s41598-024-70101-6 ↗
  4. https://app.tamarind.bio/tools/tempro ↗

Commercial fee — Unverified

No complete model + checkpoint + cloud compute + service charges have been verified. Public research software or downloadable weights do not imply a free commercial deployment.

Original evidence · reviewed 2026-10-18
  1. https://github.com/Jerome-Alvarez/TEMPRO ↗
  2. https://github.com/Jerome-Alvarez/TEMPRO/blob/main/README.md ↗
  3. https://doi.org/10.1038/s41598-024-70101-6 ↗
  4. https://app.tamarind.bio/tools/tempro ↗

Official references

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