PyRosetta
Python interface to Rosetta for protein modelling and design.
Developer: RosettaCommons / University of Washington
Overview
- Developer
- RosettaCommons / University of Washington
- Category
- MD and refinement
- Commercial rights
- Restricted
- Commercial cost
- Paid licence
- Compute
- CPU
- Open weights
- Yes
- Last verified
Capabilities
Rosetta's Python API. Input: structures and movers you script; output: relaxed/minimised and scored structures, interface metrics (ddG), loop remodelling and packing. Dependency of several design pipelines.
When to use it
Still the most complete toolbox for interface scoring, relaxation, loop modelling and FastRelax used by many design pipelines. The commercial license cost is the main blocker, and energies are not affinities.
Input / Output
- Input
- structures and movers you script
- Output
- relaxed/minimised and scored structures, interface metrics (ddG), loop remodelling and packing
Compute
Commercial Licensing
Commercial rights — may a company use it?
RestrictedLicence as writtenRosettaCommons license (free academic/non-profit; paid commercial)
The official licensing page states licensing is free for academic and non-profit institutions and available to commercial users for a fee, handled through Rosetta Commons. A commercial entity needs a paid license.
Some commercial use is possible, but a component, dependency or condition needs a paid licence or carries obligations.
Commercial cost — is commercial use free of charge?
Paid commercial licenceFree for academic and non-profit users; commercial users pay a licence fee, quoted by RosettaCommons/UW on request rather than published as a list price. This is the single most common hidden cost in otherwise-free design pipelines (BindCraft, several Rosetta-based filters).
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- pyrosetta.org
- Licence sources
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