IgDesign
Antigen-conditioned inverse-folding model for antibody CDR sequence design.
Developer: AbSci Bio; Shanehsazzadeh et al.
Overview
- Developer
- AbSci Bio; Shanehsazzadeh et al.
- Category
- antibody-specific design
- Commercial rights
- Unverified
- License fee
- Unverified
- Open weights
- Yes
- Last verified
- 2026-10-18
- Added
- 2026-10-18
Capabilities
Inputs an antibody-antigen complex backbone and target/framework context to design HCDR3 or multiple heavy-chain CDRs; produces sequence candidates and model scores. Authors describe in-vitro validation across therapeutic antigens; published outcomes are not replicated here.
When to use it
Generate antigen-targeted heavy-chain CDR variants when backbone context is available, then verify folding, receptor competition, binding and developability experimentally.
Compute
Compute category: single-gpu. See original installation instructions or platform terms for specific hardware costs and runtime.
Example use cases
- Generate antigen-targeted heavy-chain CDR variants when backbone context is available, then verify folding, receptor competition, binding and developability experimentally.
Source-based workflow description. No experimental performance ranking is implied.
Known limitations
- Repository shows MIT code and pretrained checkpoint download scripts. Model data terms, dependencies and any patents require separate review; do not claim commercial clearance from code alone.
Check the original linked sources and the terms of every model dependency.
Commercial licensing
Commercial permission — Unverified
MIT for published GitHub source code; checkpoint, data and dependency rights not comprehensively reviewed.
Repository shows MIT code and pretrained checkpoint download scripts. Model data terms, dependencies and any patents require separate review; do not claim commercial clearance from code alone.
Commercial fee — Unverified
No complete model + checkpoint + cloud compute + service charges have been verified. Public research software or downloadable weights do not imply a free commercial deployment.
Official references
Validate your designed binder.
Seq2Study coordinates expression, affinity, stability and developability testing for AI-designed antibodies and proteins.