Genie 3
All-atom SE(3)-equivariant diffusion model for protein generation, motif scaffolding and binder design.
Developer: Yeqing Lin and AlQuraishi laboratory collaborators
Overview
- Developer
- Yeqing Lin and AlQuraishi laboratory collaborators
- Category
- protein design
- Commercial rights
- Unverified
- License fee
- Unverified
- Open weights
- Yes
- Last verified
- 2026-10-18
- Added
- 2026-10-18
Capabilities
Generates protein backbones with all-atom equivariant diffusion, including targeted binder and motif-scaffolding tasks. Code includes a broader evaluation pipeline with ColabFold and other third-party components.
When to use it
Generate novel protein backbones and mini-protein binders before independent cofolding and physical binding validation; do not treat in-silico filter success as experimental hit rate.
Compute
Compute category: single-gpu. See original installation instructions or platform terms for specific hardware costs and runtime.
Example use cases
- Generate novel protein backbones and mini-protein binders before independent cofolding and physical binding validation; do not treat in-silico filter success as experimental hit rate.
Source-based workflow description. No experimental performance ranking is implied.
Known limitations
- Repo documents available checkpoint downloads. Full evaluation pipeline installs third-party tools with potentially different licenses; any commercial use needs dependency and checkpoint review.
Check the original linked sources and the terms of every model dependency.
Commercial licensing
Commercial permission — Unverified
Apache-2.0 for GitHub project; full weights and installed external evaluation components not all independently cleared.
Repo documents available checkpoint downloads. Full evaluation pipeline installs third-party tools with potentially different licenses; any commercial use needs dependency and checkpoint review.
Commercial fee — Unverified
No complete model + checkpoint + cloud compute + service charges have been verified. Public research software or downloadable weights do not imply a free commercial deployment.
Official references
Validate your designed binder.
Seq2Study coordinates expression, affinity, stability and developability testing for AI-designed antibodies and proteins.