AntiFold
Antibody-specific inverse folding, fine-tuned from ESM-IF1.
Developer: OPIG (Oxford Protein Informatics Group) and collaborators
Overview
- Developer
- OPIG (Oxford Protein Informatics Group) and collaborators
- Commercial rights
- Commercial OK
- Commercial cost
- Free commercially
- Compute
- CPU
- Open weights
- Yes
- Last verified
Capabilities
Designs antibody sequences for a given Fv backbone. Input: an antibody structure (PDB) with the regions to redesign, e.g. specific CDRs; output: per-position amino-acid probabilities and sampled sequences that keep the fold - the antibody-tuned counterpart to ProteinMPNN.
When to use it
Use instead of plain ProteinMPNN whenever the backbone is an antibody: it respects antibody sequence statistics and is the practical tool for CDR resurfacing and affinity-maturation libraries. Runs on CPU.
Input / Output
- Input
- an antibody structure (PDB) with the regions to redesign, e.g. specific CDRs
- Output
- per-position amino-acid probabilities and sampled sequences that keep the fold - the antibody-tuned counterpart to ProteinMPNN
Compute
Commercial Licensing
Commercial rights — may a company use it?
Commercial use OKLicence as writtenBSD 3-Clause License (code and the released model weights)
The repo LICENSE is BSD 3-Clause, and the README's model section links the weight download alongside an explicit 'License: BSD 3-Clause' line for those weights. One caveat read in the same README: an optional --esm_if1_mode runs ESM-IF1 weights instead, which carry Meta's own terms - check those if you use that flag.
The licence read at the source allows use by a company. Attribution or copyleft conditions may still apply — read the note.
Commercial cost — is commercial use free of charge?
Free for commercial useFree: BSD 3-Clause for both code and weights, no fee.
Price and rights are separate: this panel is about money, the panel above is about permission.
- Commercial OK ≠ Free of charge. A tool can be licensed for company use and still need a paid licence for a dependency (BindCraft → PyRosetta).
- Free download ≠ Commercially licensed. Weights you can download at no cost may still forbid commercial use (AlphaFold 3).
- Unverified ≠ Commercially permitted. If no published statement settles it, treat it as unknown — not as a yes.
- Every component counts. Each status considers the code licence, the model-weights terms, required dependencies and any terms of use.
Model Weights
Open weights. A separate weights licence is Not documented as its own field; where weights carry different terms from the code, that is stated in the licence explanation above.
Dependencies
Not documented as a separate field. Any dependency that affects commercial use (for example a paid PyRosetta licence) is named in the licence and cost explanations above.
Official References
- Official site / repo
- github.com/oxpig/AntiFold
From the makers of FoldScout
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